Escitalopram/reboxetine combination in depressed patients with substance use disorder
by
Camarasa X, Lopez-Martinez E, Duboc A, Khazaal Y, Zullino DF.
Hopital Psychiatrique Cantonal de Marsens, Switzerland.
Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jan;29(1):165-8

ABSTRACT

Acting pharmacologically on different transmitter systems has been suggested to have some advantages in patients with substance abuse and may possibly address a larger spectrum of symptoms. One major drawback of using antidepressants addressing several neurotransmitters is that the relative activities on the different neurotransmitters cannot individually be adjusted. Combining antidepressants targeting different neurotransmitter systems may allow adapting the effect on each neurotransmitter system corresponding to patients' response and tolerance. Three cases of patients presenting a substance use disorder with comorbid major depression episodes are presented, who were treated with a reboxetine/escitalopram combination and who showed a rapid response of their depressive syndrome.

Selectivity
Reboxetine
NARIs v SSRIs
Switching from Prozac
Reboxetine: product info
Noradrenergic antidepressants
Noradrenaline and cerebral aging
Reboxtine versus fluoxetine (Prozac)

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